The Belgium authorities have updated the 'Arrêté royal réglementant les substances stupéfiantes, psychotropes et soporifiques' (Royal decree regulating narcotic, psychotropic and soporific substances) with dozens of new substances, in addition to changing the schedules other substances are listed under.
Joe Bradley is a Biochemist with decades of experience in controlled drug regulations, drug discovery and cheminformatics. He has spent the last 12 years working to improve controlled drug and regulatory compliance within the chemicals and pharmaceuticals industry, through the development of software solutions which allows the rapid and accurate identification of controlled and regulated chemicals.
He founded Scitegrity in 2011 and the tools he helped create are now used by many of the worlds top chemical and pharmaceutical companies, specialist controlled drug suppliers and regulators.
He has consulted for regulators globally, helping to refine and assess the impact of proposed controlled drug regulations before final enactment.
When not absorbed in chemical regulations you'll find him on is skateboard, trials bike or with snooker cue in hand.
The collated changes are in the table below and came into force on the 16th of January 2026, although were only published a week later. If you are struggling to understand how these changes may impact your organisation, you can contact Scitegrity about our Controlled Substances Squared platform which will allow you to easily and quickly upload your chemical structures, for an instant determination if they are controlled, including against under 'Arrêté royal réglementant les substances stupéfiantes, psychotropes et soporifiques'. You can then ask the system to automatically check all your chemicals each week and alert you if any become controlled due to legislation updates.
For details of the comment “Previously generic hit (controlled under chemical space definition)” please see this previous blog on generic statement “chemical space” controls.
|
|
Name |
Chemical name |
Annex |
Comment |
|
1 |
Butonitazene |
|
IA |
Moved from Annex IVB |
|
2 |
3-CMC |
|
IIB |
Moved from IIC |
|
3 |
Bromazolam |
|
III |
Moved from IVB |
|
4 |
Dipentylone |
|
IIB |
Previously generic hit (controlled under chemical space definition) |
|
5 |
2-FDCK |
|
IIB |
Moved from IVB |
|
6 |
Clodesnitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
7 |
3,4-DMCP |
|
IVB |
New added substance |
|
8 |
N-Desethyl etonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
9 |
N-Desethyl isotonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
10 |
N-Desethyl metonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
11 |
N-Desethyl protonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
12 |
N,N-Dimethyl etonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
13 |
Ethyleneoxynitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
14 |
Fluetonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
15 |
Fluetonitazepyne |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
16 |
Flunitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
17 |
Isobutonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
18 |
Isotodesnitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
19 |
Isotonitazepyne |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
20 |
Methylallylescalin |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
21 |
6-Methyl Etazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
22 |
Alpha-methyl metonitazene |
|
IVB |
New added substance |
|
23 |
Alpha-methyl etonitazene |
|
IVB |
New added substance |
|
24 |
Metonitazepyne |
|
IVB |
Previously generic hit |
|
25 |
Alpha-PCYP |
|
IVB |
New added substance |
|
26 |
N-piperidinyl isotonitazene |
|
IVB |
Previously generic hit |
|
27 |
N-piperidinyl metonitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
28 |
Protonitazepipne |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
29 |
Protonitazepyne |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
30 |
N-pyrollidino etodesnitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
31 |
N-pyrollidino metodesnitazene |
|
IVB |
Previously generic hit (controlled under chemical space definition) |
|
32 |
THCB Isomers + stereoisomers |
|
IVB |
Previously D9-THCB in Annex IVB |
|
33 |
THCH Isomers + stereoisomers |
|
IVB |
Previously D9-THCH in Annex IVB |
|
34 |
THCP Isomers + stereoisomers |
|
IVB |
Previously D9-THCP in Annex IVB |
|
35 |
THCjd Isomers + stereoisomers |
|
IVB |
Previously D9-THCjd in Annex IVB |
Do you want to be able to easily and automatically check if your chemicals are controlled and regulated around the world - even for novel and propriatory chemicals - then you need Controlled Substances Squared.