The Belgium authorities have updated the 'Arrêté royal réglementant les substances stupéfiantes, psychotropes et soporifiques'

The Belgium authorities have updated the 'Arrêté royal réglementant les substances stupéfiantes, psychotropes et soporifiques' (Royal decree regulating narcotic, psychotropic and soporific substances) with dozens of new substances, in addition to changing the schedules other substances are listed under.

 

JoeGreyscale2021About the author

Joe Bradley is a Biochemist with decades of experience in controlled drug regulations, drug discovery and cheminformatics. He has spent the last 12 years working to improve controlled drug and regulatory compliance within the chemicals and pharmaceuticals industry, through the development of software solutions which allows the rapid and accurate identification of controlled and regulated chemicals.

He founded Scitegrity in 2011 and the tools he helped create are now used by many of the worlds top chemical and pharmaceutical companies, specialist controlled drug suppliers and regulators.

He has consulted for regulators globally, helping to refine and assess the impact of proposed controlled drug regulations before final enactment.

When not absorbed in chemical regulations you'll find him on is skateboard, trials bike or with snooker cue in hand.

 

The collated changes are in the table below and came into force on the 16th of January 2026, although were only published a week later. If you are struggling to understand how these changes may impact your organisation, you can contact Scitegrity about our Controlled Substances Squared platform which will allow you to easily and quickly upload your chemical structures, for an instant determination if they are controlled, including against under 'Arrêté royal réglementant les substances stupéfiantes, psychotropes et soporifiques'. You can then ask the system to automatically check all your chemicals each week and alert you if any become controlled due to legislation updates.

For details of the comment “Previously generic hit (controlled under chemical space definition)” please see this previous blog on generic statement “chemical space” controls.

Name

Chemical name

Annex

Comment

1

Butonitazene

IA

Moved from Annex IVB

2

3-CMC

IIB

Moved from IIC

3

Bromazolam

III

Moved from IVB

4

Dipentylone

IIB

Previously generic hit (controlled under chemical space definition)

5

2-FDCK

IIB

Moved from IVB

6

Clodesnitazene

IVB

Previously generic hit (controlled under chemical space definition)

7

3,4-DMCP

IVB

New added substance

8

N-Desethyl etonitazene

IVB

Previously generic hit (controlled under chemical space definition)

9

N-Desethyl isotonitazene

IVB

Previously generic hit (controlled under chemical space definition)

10

N-Desethyl metonitazene

IVB

Previously generic hit (controlled under chemical space definition)

11

N-Desethyl protonitazene

IVB

Previously generic hit (controlled under chemical space definition)

12

N,N-Dimethyl etonitazene

IVB

Previously generic hit (controlled under chemical space definition)

13

Ethyleneoxynitazene

IVB

Previously generic hit (controlled under chemical space definition)

14

Fluetonitazene

IVB

Previously generic hit (controlled under chemical space definition)

15

Fluetonitazepyne

IVB

Previously generic hit (controlled under chemical space definition)

16

Flunitazene

IVB

Previously generic hit (controlled under chemical space definition)

17

Isobutonitazene

IVB

Previously generic hit (controlled under chemical space definition)

18

Isotodesnitazene

IVB

Previously generic hit (controlled under chemical space definition)

19

Isotonitazepyne

IVB

Previously generic hit (controlled under chemical space definition)

20

Methylallylescalin

IVB

Previously generic hit (controlled under chemical space definition)

21

6-Methyl Etazene

IVB

Previously generic hit (controlled under chemical space definition)

22

Alpha-methyl metonitazene

IVB

New added substance

23

Alpha-methyl etonitazene

IVB

New added substance

24

Metonitazepyne

IVB

Previously generic hit

25

Alpha-PCYP

IVB

New added substance

26

N-piperidinyl isotonitazene

IVB

Previously generic hit

27

N-piperidinyl metonitazene

IVB

Previously generic hit (controlled under chemical space definition)

28

Protonitazepipne

IVB

Previously generic hit (controlled under chemical space definition)

29

Protonitazepyne

IVB

Previously generic hit (controlled under chemical space definition)

30

N-pyrollidino etodesnitazene

IVB

Previously generic hit (controlled under chemical space definition)

31

N-pyrollidino metodesnitazene

IVB

Previously generic hit (controlled under chemical space definition)

32

THCB Isomers + stereoisomers
  • 3-butyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-butyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6Hdibenzo[b,d]pyran-1-ol 3-butyl-6,6,9-trimethyl-8,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-butyl-6,6,9-trimethyl-6a,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-butyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-butyl-6,6,9-trimethyl-6a,7,8,9-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-butyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol

IVB

Previously D9-THCB in Annex IVB

33

THCH Isomers + stereoisomers
  • 3-hexyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol 3-hexyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-hexyl-6,6,9-trimethyl-8,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-hexyl-6,6,9-trimethyl-6a,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-hexyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-hexyl-6,6,9-trimethyl-6a,7,8,9-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-hexyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol

IVB

Previously D9-THCH in Annex IVB

34

THCP Isomers + stereoisomers
  • 3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-heptyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6Hdibenzo[b,d]pyran-1-ol 3-heptyl-6,6,9-trimethyl-8,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-heptyl-6,6,9-trimethyl-6a,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-heptyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-heptyl-6,6,9-trimethyl-6a,7,8,9-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol

IVB

Previously D9-THCP in Annex IVB

35

THCjd Isomers + stereoisomers
  • 3-octyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol 3-octyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-octyl-6,6,9-trimethyl-8,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-octyl-6,6,9-trimethyl-6a,9,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-octyl-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-octyl-6,6,9-trimethyl-6a,7,8,9-tetrahydro-6Hdibenzo[b,d]pyran-1-ol
  • 3-octyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6Hdibenzo[b,d]pyran-1-ol

IVB

Previously D9-THCjd in Annex IVB

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